In contrast to Cannabinoids, THC is partial agonist of above mentioned receptors with higher binding with CB1. They can modulate variety of physiological responses such as pain, memory, inflammation, appetite, behavior etc. Cannabinoids are now recognized more because of their relation with human endocannabinoid system which includes two G proteincoupled cannabinoid receptors (CB1 and CB2) and two ligands (anandamide and 2-arachidonylglycerol). Mechoulam (2005) described hemp as “neglected pharmacological treasure trove”. This act came after International Treaty of 1961 regarding Narcotics Substances.Īlso Read: Benefits of Joining IC InnovatorCLUB sativa or Vijaya) as sacred drink during Lord Shiva related rituals, though its cultivation was legally banned in 1985 by Narcotic Drugs and Psychotropic Substances Act. Ironically, since ages peoplein India have been consuming bhang milkshake (a preparation of C. The seeds and leaves are permitted for usage depending on state policy though licensing. Phytocannabinoids accumulate in the secretory cavity of the glandular trichomes, which largely occur in female flowers and in most aerial parts of the plants. Flower and bud trichome’s release psychotropic substances formulated as charas, hashish and ganja.
The processing of flower and buds of Cannabis is illegal in India. The use of flowers/buds for cannabidiol (CBD), a non-addictive substance, is extremely useful for pharmacological formulation managing chronic pain, anxiety, inflammation, depression etc.Īlso Read: Study: Increasing Protein and Dairy Intake Reduce Burden of Diabetes The recent advances in CBD research and identification of Cannabinoid receptors in human revolutionized its importance in western pharmacology. It can be a useful source of non-psychotropic cannabidiol (CBD). Cannabis sativa, due to its close relative Cannabis indica (high THC Cannabis), always remained under shadow. Historical evidence of its use can be traced in ancient literature Atharvaveda (1500 BC) Sushruta Samhita for treatment of phlegm and diarrhea and Persian medical text of 18th century (UnaniTibbi). It is known for its use in paper industry, textile, biodegradable plastics, paint, biofuel, food and feed. Hemp or Cannabis sativa with limited concentration of an active psychotropic substance tetrahydrocannabinol (THC) <0.3% is a promising industrial crop.
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